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Lasergene

Description

DNASTAR Lasergene is a software suite that contains programs and tools dedicated to four overarching data analysis workflows:

The licenses available to NCI researchers only provide access to the Molecular Biology (Lasergene Molecular Biology) and Protein Analysis and Modeling packages (Lasergene Protein). Therefore, the tools available largely exclude high- throughput data.

Lasergene Molecular Biology

The Lasergene Molecular Biology package includes the following applications: SeqBuilder Pro, SeqMan Ultra, MegAlign Pro, GeneQuest, GenVision, SeqNinja, and DNASTAR Navigator.

These applications provide tools to perform in silico gel electrophoresis and cloning, plasmid vector annotation, cloning verification, sequence editing and annotation, multiple sequence alignment and pairwise alignments, PCR primer design, Sanger sequence assembly, and DNA translation.

Lasergene Protein

The Lasergene Protein package includes Protean 3D (+1 prediction per Nova Application) and DNASTAR Navigator.

The protein analysis and modeling workflow provides tools pertinent to antibody modeling, protein docking interaction prediction, epitome prediction, molecular motion visualization, protein design and engineering, protein sequence analysis, structural alignment, structural analysis, and structure prediction.

Recommendations

Included applications are fairly easy to navigate even for individuals with little to no bioinformatic experience. Tools facilitate the planning of molecular biology experiments and produce publishable visualizations.

Lasergenes' molecular biology application is recommended for Sanger sequencing analysis or for designing experimental assays rather then whole genome alignment.

Things to Know

  • Must gain access to the NIH network to use the license
  • GenVision is available for Windows only.
  • Not recommended for NGS analysis

Input and Output Data Types

Because DNASTAR Lasergene includes a wide array of applications, there is a large number of input and output data types that vary by application. Fortunately, there is an extensive list provided on the commercial website.

Access Information

You must submit a request through “service.cancer.gov” to obtain access to LaserGene Software. This software requires access to a floating license server. Please close the application when not in use so that others may gain access.

Getting Help

Each DNASTAR Lasergene application is well documented with help pages and tutorials. See the website tutorial page for more information.