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From One Cell to Multiple Molecular Views: A Practical Introduction to Single-Cell Multi-omics

Speaker: Stefan Cordes, PhD, MD (NHLBI)

This session introduced major concepts and practical workflows for single-cell multi-omics, with emphasis on paired same-cell measurements such as CITE-seq and single-cell RNA+ATAC multiome, as well as integration of unpaired and spatial modalities. Dr. Cordes discussed how transcriptomic, protein, chromatin-accessibility, genotype/repertoire, perturbation, and spatial readouts can be combined to improve cell-state annotation and biological interpretation, with practical examples comparing Seurat/Signac and scverse-oriented workflows.

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