Computational Tools to Study mRNA Isoform Variation in Cancer

About this Class

Meeting Link: https://cbiit.webex.com/cbiit/j.php?MTID=m14c6833bc06f89408464fac5bb2e8ce9 Human cells generate remarkable regulatory and functional complexity from a finite set of genes. Production of mRNA isoforms through alternative RNA processing and modifications is essential for generating this complexity. With the rapid accumulation of cancer RNA-seq data in public repositories, there is an unprecedented opportunity to elucidate the landscape and functional consequence of mRNA isoform variation in cancer. In this talk, Dr. Xing will discuss his lab’s computational tools for characterizing mRNA isoform variation, as well as key biological insights obtained when applying these tools to massive RNA-seq data across cancer and normal transcriptomes. Collectively, they have uncovered mRNA isoforms and associated regulatory networks that play crucial roles in tumor development and progression and have identified novel targets for therapy development. Following the webinar, there will be a Question and Answer session for anyone with questions about mRNA isoform computational tools (rMATS, DARTS, new tools) from 2:00 to 3:00 p.m. It will be held at the same meeting link as the webinar.