Expanding Proteogenomics to Map the Proteoform Landscape of Human Tumors

About this Class

Speaker: Neil L. Kelleher, Ph.D. Walter and Mary E. Glass Professor of Molecular Biosciences Professor of Chemistry in the Weinberg College of Arts and Sciences Professor of Medicine (Hematology & Oncology) in the Feinberg School of Medicine Director, Chemistry of Life Processes Institute & Northwestern Proteomics Northwestern University Dr. Kelleher received his Ph.D. from Cornell University and completed his postdoctoral training from Harvard Medical School. He then joined the faculty at the University of Illinois at Urbana-Champaign where he established research program in proteomics. In 2010, he joined the faculty at the Northwestern University. Dr. Kelleher's Team is built around expertise in technology development for complex mixture analysis using Fourier-Transform Mass Spectrometry for targeted applications in proteomics and metabolomics. His lab leverages top-down proteomics, which is the analysis of intact proteins for precise localization of post-translational modifications to advance the understanding of chromatin and cancer biology. Dr. Kelleher is a pioneer of the top-down approach and the Human Proteoform Project (HPfP), a global research initiative to weigh every protein in the human body, 250,000 proteoforms (specific molecular form of a gene product) in 4,000 different cell types. This will enable dramatic increases in the speed and efficiency by which investigators can identify higher-value protein-based markers of disease including cancer, and spur game-changing advances in biomedical research, drug development and human health. Dr. Kelleher developed the ProSight PTM software platform that allows identification and characterization of both intact proteins and peptides. This is the only proteomics software that allows the user to search their tandem MS data against proteome warehouses containing the known biological complexity present in UniProt (a resource of protein sequence and functional information). Dr. Kelleher has co-authored over 300 articles in peer-reviewed journals including Science, Nature Methods, PNAS, Cancer Discovery, Mol. Cell. Proteomics, J. Cell Biol., and J Biol Chem. Dr. Kelleher received many awards including Biermann Medal (American Society for Mass Spectrometry), Pfizer Award in Enzyme Chemistry (American Chemical Society, DBC), Presidential Early Career Award in Science and Engineering, National Science Foundation CAREER Award, Burroughs Wellcome Award in the Pharmacological Sciences, and American Society of Mass Spectrometry Research Award. Meeting number (access code): 2309 555 7341 Meeting password: 4qrPy7wAm*2