About this Class

This seminar will discuss how we can leverage shared data to discover signatures of human vaccination and infection responses. A key example will be work done as part of the NIH Human Immunology Project Consortium (HIPC)(link is external) where data from ImmPort(link is external) was compiled and reanalyzed to identify pre-vaccination and temporal signatures of antibody responses that were shared across multiple vaccines.

About the Speaker

Professor Steven Kleinstein is a computational immunologist with a combination of big data analysis and immunology domain expertise. His research interests include both developing new computational methods and applying these methods to study human immune responses. His lab develops the widely used Immcantation framework(link is external), which provides a start-to-finish analytical ecosystem for high-throughput adaptive immune receptor repertoire sequencing (AIRR-seq) datasets. He currently co-leads the data coordinating center for the NIH Human Immunology Project Consortium (HIPC)(link is external).

Prof. Kleinstein is Anthony N. Brady Professor of Pathology at the Yale School of Medicine where he co-directs the Program in Computational Biology & Bioinformatics(link is external). He received a B.A.S. in Computer Science from the University of Pennsylvania and a Ph.D. in Computer Science from Princeton University.