Mapping Cancer Genetics at Single Cell Resolution

About this Class

Speaker: Dr. Luke Gilbert is an Assistant Professor in the Department of Urology, the Helen Diller Family Comprehensive Cancer Center and the Innovative Genomics Institute at the University of California, San Francisco. Dr. Gilbert was an early pioneer in repurposed CRISPR systems that are used to turn genes on (CRISPRa) and off (CRISPRi) by editing the epigenome. The Gilbert lab continues to develop new epigenetic editing approaches as well as new CRISPR functional genomics platforms. Recently, the Gilbert lab developed two next-generation CRISPR functional genomics platforms to systematically and quantitatively map genetic interactions. The Gilbert lab is focusing on utilizing our expertise to tackle big problems in cancer such as metastasis and drug resistance in cancer. They use genome-scale screens, genetic interaction mapping and genome engineering to identify genetic and epigenetic causes underlying why some patients are cured and others are not by cancer therapy. Registration