Probing Cancer Metabolism for Therapeutic Opportunities

About this Class

Presenter: Gary Patti, Ph.D. Departments of Chemistry, Genetics, and Medicine Washington University in St. Louis It is well established that the metabolism of cancer cells is reprogrammed to support the demands of rapid proliferation. However, a comprehensive map of metabolic adaptations that occur as a result of malignant transformation has yet to be achieved. This talk will focus on the application of mass spectrometry-based metabolomics to broaden our understanding of metabolic alterations in cancer, with the ultimate goal of identifying biochemical liabilities that can be exploited therapeutically. To increase insight, data from multiple experimental paradigms of metabolomics will be described in detail, including (i) global, untargeted profiling, (ii) isotope-tracer analysis, and (iii) dose-response metabolomics. Dr. Patti will dedicate particular attention to computational resources available for data processing, such as those supported by the NIH Metabolomics Common Fund. Dr. Patti will also review the workflow covering metabolic profiling to drug selection and target validation in an imals and discuss opportunities for polypharmacology. Event contacts: Krista Zanetti, zanettik@mail.nih.gov and Catherine Yu, catherine.yu@nih.gov