Proteomic analysis of cancer internal heterogeneity

About this Class

Register Cancer heterogeneity is one of the major challenges that hampers the ability to cure the disease. Tumors differ in their genetic profiles and the cellular interactions in the microenvironment, and each tumor may have multiple different clones with distinct molecular characteristics. Therefore understanding cancer heterogeneity has major translational implications. In my lab we use mass spectrometry-based proteomics to understand cancer heterogeneity in breast cancer and melanoma. We combine analysis of clinical samples with histopathological analysis and functional validations, to unravel novel regulators of cancer progression. Analysis of hundreds of breast cancer tumor regions associated between clinical parameters and the protein networks, and showed their heterogeneity within single tumors. Our research showed the importance of each clinical feature and the significance of the immune system in affecting tumor heterogeneity. We also showed the microenvironment effects on melanoma, in the context of immunotherapy response. These unsupervised proteomic networks set the basis for future improved therapy and precision oncology. Presenter: Dr. Tami Geiger, from the Sackler Faculty of Medicine, Tel Aviv University, Israel. Meeting ID: 916 3499 0819 One tap mobile +13017158592,,91634990819# US (Washington D.C) +19294362866,,91634990819# US (New York) Dial by your location +1 301 715 8592 US (Washington D.C) +1 929 436 2866 US (New York) +1 312 626 6799 US (Chicago) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) Meeting ID: 916 3499 0819 Find your local number: https://umd.zoom.us/zoomconference?m=O4DLGIb-r68F6tV586-lZPIBn4AGVlpe&_x_zm_rtaid=XmaBsPGmTeufOfL1u9ZYCg.1605297715617.1ba59dbec70972ce94cb94737a2e8ad5&_x_zm_rhtaid=242 Join by H.323 162.255.37.11 (US West) 162.255.36.11 (US East) 115.114.131.7 (India Mumbai) 115.114.115.7 (India Hyderabad) 213.19.144.110 (Amsterdam Netherlands) 213.244.140.110 (Germany) 103.122.166.55 (Australia) 149.137.40.110 (Singapore) 64.211.144.160 (Brazil) 69.174.57.160 (Canada) 207.226.132.110 (Japan) Meeting ID: 916 3499 0819