Telomere-to-telomere (T2T) Genome Assemblies: Shining a Light on Repeat Biology and Chromosome Dynamics

Distinguished Speakers Seminar Series

Telomere-to-telomere (T2T) Genome Assemblies: Shining a Light on Repeat Biology and Chromosome Dynamics

 When: Sep. 12th, 2024 1:00 pm - 2:00 pm

This class has ended.

Video Archive *Class recordings may take ~48 hours to become available.

Seminar Series Details:

Presented By:

Rachel O'Neill, Ph.D. (Univ. of Connecticut)

Where:

Online Webinar

Organized By:

BTEP

About Rachel O'Neill, Ph.D. (Univ. of Connecticut)

John and Donna Krenicki Professor in Genomics and Personalized Healthcare UConn

Board of Trustees Distinguished Professor

Director, Institute for Systems Genomics

Director, Center for Genome Innovation | Institute for Systems Genomics

Professor, Genetics and Genomics | Dept. of Molecular and Cell Biology

Professor, Dept. of Genetics and Genome Sciences | UConn Health

About this Class

Telomere to telomere (T2T) genome assemblies represent a paradigm shift in comparative genomics, offering insights into chromosome structure, evolution, and function at the highest resolution. Dr. O'Neill's lab has made recent efforts employing long-read based genome assembly, coupled with epigenetic, functional and repeat analyses, which have afforded the opportunity to delineate key elements participant in centromere function and chromosome rearrangement. Using a comparative approach and long-read, gapless genome assemblies, their studies provide insight into the diversity, distribution, and evolution of repetitive regions that shape chromosome structure and evolution in human and in species groups experiencing rapid karyotypic change.