Single Cell Seminar Series
Single Cell Annotation with SingleR: Macrophage-fibroblast crosstalk in lung fibrosis
When: Jun. 22nd, 2023 1:00 pm - 2:00 pm
Presented By: Mallar Bhattacharya, M.D. (UCSF)
Mallar Bhattacharya, M.D.
Dept. of Medicine
University of California, San Francisco (UCSF)
About this Class
The Bhattacharya Lab at the UCSF Parnassus Campus is focused on the functional role of monocyte-derived macrophages in the onset and persistence of fibrosis in the lung. We are addressing the following major questions, with a goal of discovering new targets for therapy for acute lung injury and fibrosis:
- What molecules released by monocyte-derived macrophages and other immune cells signal to and activate pro-fibrotic programs in parenchymal cell types such as fibroblasts and epithelial cells?
- What reciprocal signals derive from these parenchymal cells to modify the immune response?
- How can this pathologic crosstalk be reversed to combat fibrosis and restore lung health?