Single cell profiling of T cell responses in non small cell lung cancer

About this Class

For our next meeting we will be having a guest lecture by Dr. Josh Waterfall from Institut Curie. Abstract: Non small cell lung cancers (NSCLC) are known to be recurrently infiltrated by multiple immune populations. Furthermore, the level of infiltration by T cell populations is a positive prognostic factor and immune checkpoint blockade provides significant clinical benefit in a subset of patients.  However, many questions remain concerning the heterogeneity and function of tumor infiltrating T cell populations.  To address these issues, we performed single cell RNA and T Cell Receptor (TCR) seq profiling of T cell subsets in a cohort of early stage NSCLC patients including tumor, juxta-tumor tissue, and blood.  This allowed development of a working model for the ontogeny, recruitment, and differentiation of these populations as well as the role of TCR signaling and proliferation within the tumor microenvironment. Join ZoomGov Meeting https://nih.zoomgov.com/j/1610990767?pwd=NzVWQzlNOTBtazJYcFBycEEyRDJVQT09 Meeting ID: 161 099 0767 Passcode: 945612 One tap mobile +16692545252,,1610990767#,,,,*945612# US (San Jose) +16468287666,,1610990767#,,,,*945612# US (New York)