BTEP maintains several Question and Answer Forums of interest to the NCI/CCR community.
Currently, there are forums on these topics listed below:
If you wish to ask a question go to the Ask Question Page and submit your question.
Local vs. global alignment
How do we decide if we should use local or global alignment?
1 Answer:
It depends on your input sequences. Local alignments are useful for finding regions of similarity between dissimilar sequences. Global alignments do more of an end-to-end alignment between two sequences. If you have two very dissimilar sequences you'll probably get a lot of gaps between your two sequences when you do a global alignment. A local alignment might be good for finding similar domains in two unrelated proteins; or maybe trying to find a transcription factor binding site in two promoter sequences. - answered by Des Tillo
Answered on June 17th, 2020 by amy.stonelake@nih.gov