An Introduction to Gene Set Enrichment Analysis and the Molecular Signatures Database

About this Class

Register Description: Over the last 15 years the Gene Set Enrichment Analysis (GSEA) software and its companion gene set collections, the Molecular Signatures Database (MSigDB) have served as key resources for interpreting the biological significance of expression changes in large transcriptomic datasets. The GSEA-MSigDB project offers free and open-source tools like GSEA - and its single-sample equivalent ssGSEA - and a large database of gene signatures curated to aid in both disease research and understanding basic biology. Our team continues to expand the utility of these resources through the additions of new analysis tools, gene sets, and integrations with other resources. This webinar will provide an introduction to some of the basics of the GSEA method, including various options for how to run GSEA, introduce some of the numerous resources available for analysis in the Molecular Signatures Database, and explore how to analyze and interpret enrichment results. Presenter: Dr. Anthony Castanza Curator, Molecular Signatures Database Mesirov Lab, Department of Medicine University of California, San Diego POC: Daoud Meerzaman