Computational integration in cancer analysis: from multi-omic to personalized drivers

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Register Meeting ID: 918 4307 1125 One tap mobile +13017158592,,91843071125# US (Washington D.C) +19294362866,,91843071125# US (New York) Dial by your location +1 301 715 8592 US (Washington D.C) +1 929 436 2866 US (New York) +1 312 626 6799 US (Chicago) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) Meeting ID: 918 4307 1125 Find your local number: https://umd.zoom.us/zoomconference?m=Y08AKWEIVGj29FpUtKvDh6XrXwrgs53r&_x_zm_rtaid=zSLTbW9bTi-h6a8E8WmlaQ.1607007521497.e7de5bcb28f707e396be7385171ba408&_x_zm_rhtaid=715 Join by H.323 162.255.37.11 (US West) 162.255.36.11 (US East) 115.114.131.7 (India Mumbai) 115.114.115.7 (India Hyderabad) 213.19.144.110 (Amsterdam Netherlands) 213.244.140.110 (Germany) 103.122.166.55 (Australia) 149.137.40.110 (Singapore) 64.211.144.160 (Brazil) 69.174.57.160 (Canada) 207.226.132.110 (Japan) Meeting ID: 918 4307 1125 Abstract: Today's large biological datasets open novel opportunities in basic science and medicine. While inquiry of each dataset separately often provides insights, integrative analysis may reveal more holistic, systems-level findings. We demonstrate the power of integrated analysis in cancer on two levels: (1) in joint analysis of multiple omics for the same cancer; (2) in identifying and ranking driver genes in an individual's tumor based on expression and mutation profiles. In both cases, we develop novel methods and observe a clear advantage of the integration. Bio: Ron Shamir received his PhD from UC Berkeley. He is a Sackler professor of Bioinformatics in the Blavatnik School of Computer Science at Tel Aviv University (TAU). His group develops algorithms in bioinformatics for understanding the genome and human disease. Software tools developed by Shamir’s group are in use around the world. Shamir is the founder and head of the Edmond J. Safra Center for Bioinformatics at TAU. He has published more than 300 scientific works, including 17 books and edited volumes, and has supervised more than 50 research students. Fifteen of his past students hold academic positions. He was on the founding steering committee of RECOMB, co-founded the Israeli Society of Bioinformatics and Computational Biology, and was society president. He is a recipient of the Landau Prize in Bioinformatics, the Kadar family prize for excellence in research, and a Fellow of the ISCB and the ACM.