Decoding the Genomics of Neurodegenerative Diseases with Large-Scale Long-Read Sequencing

About this Class

The last decade has demonstrated the power of genomics to unravel the etiology of complex traits and diseases. The vast majority of genomic studies have been based on mostly short read sequencing technologies (50-200 base pair fragments). With the development of long-read sequencing (such as Oxford Nanopore or Pacific Biosciences), it is now possible to routinely sequence fragments of 10-100 kilo bases and longer. At the same time, long-range linkage technologies such as Hi-C or Strand-Seq can be used to profile chromosome-scale interactions. The Long-read and Long-range Sequencing Scientific Interest Group hosts a monthly seminar series focused on these new technologies and their applications.