Emergent cellular ecosystems in melanoma revealed by single cell analysis

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Presenter: Dr. Arjun Raj from the Perelman School of Medicine, UPenn. Abstract:Anti-cancer therapies can often kill the vast majority of tumor cells but a few rare cells remain and grow despite treatment. Non-genetic variability has emerged as a potential contributor to this behavior. However, it remains unclear what drives this variability, and what the ultimate phenotypic consequences are. We have developed a set of new single cell barcoding technologies (Rewind and FateMap) that have enabled us to show how different types of variability can translate into different drug-resistant outcomes upon treatment with drugs. In particular, we found that even a genetically and epigenetically clonal population harbors enough latent variability to produce an entire ecosystem of different resistant cell types, and show preliminary evidence suggesting that these cell types can contribute to tumor development in distinct ways. Meeting details: Join Zoom Meeting https://umd.zoom.us/j/91843071125 Meeting ID: 918 4307 1125 One tap mobile +13017158592,,91843071125# US (Washington D.C) +19294362866,,91843071125# US (New York) Dial by your location +1 301 715 8592 US (Washington D.C) +1 929 436 2866 US (New York) +1 312 626 6799 US (Chicago) +1 346 248 7799 US (Houston) +1 669 900 6833 US (San Jose) +1 253 215 8782 US (Tacoma) Meeting ID: 918 4307 1125 Find your local number: https://umd.zoom.us/u/abASyXtwsH Thanks, Sushant