Harnessing NIAID’s ImmPort & NASA’s GeneLab Through Computational and Systems Biology Approach: Determining Female Health Risks for Spaceflight Driven by MicroRNAs

About this Class

In the era of renewed space exploration, understanding female health risks during spaceflight is essential. This talk focuses on leveraging NIAID's ImmPort and NASA's GeneLab data using computational and systems biology to investigate microRNA (miRNA)-driven risks for female astronauts. We identified a shared miRNA signature linked to small-for-gestational-age (SGA) outcomes in both humans and mice, suggesting that space stressors may elevate reproductive risks. Machine learning techniques revealed FDA-approved drugs, including hormone receptor and vitamin D receptor antagonists, as potential countermeasures. Our findings highlight the need for targeted interventions to protect female health during and after space missions.