Introduction to Cancer Proteome Atlas

About this Class

Register Presenter: Dr. Han Liang Reverse-phase protein arrays (RPPAs) offer a powerful functional proteomic approach to evaluate biomarkers and mechanisms underlying sensitivity and resistance to cancer therapy. The MD Anderson Cancer Center platform currently contains ~500 protein markers, covering all major signaling pathways. The Cancer Proteome Atlas (TCPA) we developed (http://tcpaportal.org) is the sole dedicated bioinformatics resource for RPPA data. Currently, it contains two analytic platforms: one contains >8000 patient samples; and the other contains >1500 cell line samples. We are developing the third component focusing on adaptive RPPA response given drug treatments. We have built an integrated data portal that contains user-friendly analytic and visualization tools for a broad biomedical community to utilize these data.To learn more please visit: https://tcpaportal.org/tcpa/ The ITCR Program is a trans-NCI program supporting investigator-initiated, research-driven informatics technology development spanning all aspects of cancer research. The ITCR Program funds tools that support the analysis of -omics, imaging, and clinical data, as well as network biology and data standards. All of the tools are free for use by academic and non-profit researchers. Access to tools, code repositories, and introductory videos are available on the website https://itcr.cancer.gov/