ITCR Webinar: Introduction to the Cancer Proteome Atlas
When: Sep. 13th, 2024 10:00 am - 11:00 am
Learning Level: Any
To Know
About this Class
Reverse-phase protein arrays (RPPAs) represent a powerful functional proteomic approach to elucidate cancer-related molecular mechanisms and develop novel cancer therapies.
To facilitate community-based investigation of the large-scale protein expression data generated by this platform, we have developed a user-friendly, open-access bioinformatic resource, The Cancer Proteome Atlas (TCPA), which contains several applications.
The first application focuses on RPPA data of patient tumors, which contains >8,000 samples of 32 cancer types from The Cancer Genome Atlas and other independent patient cohorts. The second focuses on the RPPA data of >1,500 cancer cell lines with publicly available, high-quality DNA, RNA and drug screening data. The third focuses on perturbed RPPA profiles of >14,000 samples given drug treatments.
To further address the informatic challenges of analyzing such diverse datasets, in addition to the GUI interfaces, we recently developed a chatbot, TPCAplus, through which users can analyze the RPPA data through human nature languages and obtain the results and related analytic reports without a learning curve.
Such a chatbot empowers a broad research community to explore high-quality RPPA datasets and generate testable hypotheses in an effective and intuitive manner, representing the direction of next-generation data analytics.
For questions, contact Daoud Meerzaman or Kayla Strauss.