Distinguished Speakers Seminar Series
Mapping the Spatial and Temporal Utilization of Cancer Cell States and Building Human-Interpretable Models of Cell State Regulation by the Micro and Macro-Environment
Seminar Series Details:
Presented By:
Genevieve Stein-O'Brien PhD (JHU)
Where:
Online
Organized By:
BTEP
About Genevieve Stein-O'Brien PhD (JHU)
Genevieve Stein O’Brien, PhD, MHS
Terkowitz Family Rising Professor
Bloomberg Assistant Professor of Neuroscience
Departments of Neuroscience, Neurology, and Genomic Medicine
Brain Science Institute
Kavli Neuroscience Discovery Institute
Kavli Neuroscience Discovery Institute
Co-Director Single-Cell Training and Analysis Center (STAC)
Johns Hopkins University, School of Medicine
About this Class
Single cell gene expression profiling has demonstrated that cell classification requires more than a simple collection of marker genes. Current approaches do not account for the dynamic nature of cell states and inherent variation in cell types. This is especially true in the central nervous system (CNS) where morphological, location, and activity- based definitions of cell types fail to correlate well with single cell transcriptional profiles. Given how cell these cell extrinsic features are essential for the collective behavior and functionality of individual cells, it is critical to resolve how cell intrinsic molecular programs interact with and affect cell extrinsic physiology.