NHLBI Proteomics Core – From proteins and post-translational modifications to systems biology

About this Class

Presenter: Dr. Marjan Gucek, director for the NHLBI Proteomic Core Summary: “Proteomics Core provides access to mass spectrometry and gel based proteomics for identification and quantitation of proteins and their post-translational modifications (PTM). Our workflows for protein quantitation are based on label-free, SILAC and TMT approaches. We can identify and quantify protein post-translational modifications, including phosphorylation, nitrosylation, acetylation, ubiquitination, succinylation, etc. We provide training in proper sample preparation and lead the researchers through mass spectrometric analysis to data searching and interpretation. I’m going to overview the technology behind our instruments and present unique challenges in protein identification and quantitation (such as dynamic range and sample complexity, especially in biological fluids).” https://nih.webex.com/nih/j.php?MTID=m237a8e77868c23cc4e8b31120408c54c Delong Liu Mondays data science and bioinformatics seminar series: Nov 16, 2020, Dr. Steve Coon, long-read sequencing, NICHD sequencing Core Nov 23, 2020, Dr. Siyuan Liu, Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans, NIMH Nov 30, 2020 (Thanksgiving) Dec 7, 2020, Dr. Jack Bibby, Using Single Cell Pathway Analysis (SCPA) to map transcriptional dynamics during early T cell activation, Dr. Kemper lab, NHLBI Dec 14, 2020, Dr. Weiniu Gan, overview of the TOPMED program, NHLBI Jan 18, 2020, Birthday of Martin Luther King, Jr. Jan 25, 2020, Dr. Gerry Bouffard/Dr. Jim Mullikin, NIH sequencing center, NIH. Feb 1, 2020, Dr. Majid Kazemian, Purdue University Feb 8, 2020, Dr. Marjan Gucek, NHLBI Proteomics core Feb 15, federal holiday Feb 22, Dr. Dawei Huang, NCI Mar 1, Dr. Oleg Shchelochkov, NHGRI Mar 8, Dr. Wolfgang Resch, CIT biowulf Mar 15, Dr. Sean Davis, NCI Mar 22, Dr. Jonathan Kaltman, the biodata catalyst program, NHLBI Mar 29, Dr. Jun Li, single-cell data analysis, University of Notre Dame Apr 5, Dr. Peng Li, Dr. Leonard Lab, NHLBI Apr 12, April 19, Dr. Adam Phillippy, the pan-genome project, NHGRI