OncoFold: Visualizing Somatic Mutations in 3D Protein Structures
To Know
Where:
Online
Organizer:
BTEP
Presented By:
Do Young Hyeon (Harvard Medical School), Felix Dietlein MD PhD (Harvard Medical School), Yuxiang Zhou (Harvard Medical School)
About this Class
OncoFold is a web resource to visualize somatic mutations in 3D protein structures. It enables researchers to interpret mutations in cancer through their structural context, explore significantly mutated regions with ligands and detailed domain annotations, identify spatial clustering indicative of positive selection, and gain mechanistic insights into how specific mutations may alter protein function and contribute to tumorigenesis.