Overview of CNV Analysis Using Nexus Copy Number Software

About this Class

Register Presenter: Dr. Sam Dougaparsad Field Application Scientist It has been established that over half of all cancer types are driven by DNA Copy Number Variants (CNVs). In this presentation, we will demonstrate the use of Nexus Copy Number software for detection of CNVs from various microarray and NGS platforms and performance of cohort analysis. In particular, we will use data from The Cancer Genome Atlas (TCGA) that has been manually curated and available to NCI personnel through the NexusDB database to showcase some of the advanced statistical and visualization capabilities of Nexus Copy Number. This will include identification of recurrent aberrations in different cancer types and sub-populations, statistical comparison analysis between different sets of samples, identification of regions with high predictive power for survival analysis and many other features. Subsequent sessions will expand on integrating expression and sequence variant data into the analysis.