Single Cell and Spatial Oncology of Pancreatic Cancer
To Know
About this Class
In this talk, Dr. Hwang will discuss three examples of applying single-cell and spatial oncology approaches to the study of pancreatic cancer. First, he will explain how they utilized single-nucleus RNA-sequencing to uncover an enriched neural-like progenitor malignant state after cytotoxic therapy. Second, he will detail the development and application of spatially-constrained optimal transport interaction analysis (SCOTIA) to reveal augmented IL6 signaling between cancer-associated fibroblasts and malignant cells in residual disease. Third, he will present their use of spatial transcriptomics to study cancer-nerve interactions, which identified PDGFD-PDGFRB signaling as a mediator of intratumoral neuroinvasion. Finally, he will discuss his thoughts on the future of spatial oncology and ongoing efforts in spatial multi-omics.