Somatic Variant Analysis and Detection Using Localized Genome Graphs

About this Class

In this seminar, you'll learn about the somatic variant caller named Lancet. This accurate, open-source tool leverages local assembly and joint analysis of tumor-normal, paired, high-throughput sequence data.

New York Genome Center’s Dr. Giuseppe Narzisi will provide an overview of:

• the methodology behind the tool.
• how it’s benchmarking against similar tools.
• improvements in computational performance.
• recent integrations with third party tools to visually inspect the somatic variants in graph space.

Dr. Narzisi will also give a historical review of alignment-based methods. He’ll highlight limitations and the need for new genome graph approaches.